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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
更昔洛韦
合成路线
（共 39 条）
1445-45-0
原乙酸三甲酯
+
82410-32-0
更昔洛韦
→
反应条件
88110-89-8
O-单乙酰更昔洛韦
反应条件
1: With trifluoroacetic acid in N,N-dimethyl-formamide T=23°C; Substitution; 2 h; 2: With water in N,N-dimethyl-formamide T=23°C; Hydrolysis;
参考文献
Magnetic Resonance in Chemistry, , vol. 38, # 8 p. 696 - 700
1445-45-0
原乙酸三甲酯
+
82410-32-0
更昔洛韦
→
反应条件
88110-89-8
O-单乙酰更昔洛韦
反应条件
trifluoroacetic acid in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Harnden; Serafinowska
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 903 - 913
82410-32-0
更昔洛韦
→
反应条件
88110-89-8
O-单乙酰更昔洛韦
反应条件
1: triethylamine 2: dicyclohexyl-carbodiimide; triethylamine 3: trifluoroacetic acid / dichloromethane / 3.17 h / 15 °C View Scheme
参考文献
Babu, K. Srihari; Rao, M. Raghavendar; Goverdhan; Srinivas; Reddy, P. Pratap; Venkateswarlu; Anand, R. Vijaya
Synthetic Communications, 2013 , vol. 43, # 13 p. 1751 - 1758
82410-32-0
更昔洛韦
→
反应条件
175865-59-5
缬更昔洛韦盐酸盐
反应条件
1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide 2.1: zinc / isopropyl alcohol / 5 - 30 °C 3.1: acetic acid; trifluoroacetic acid / isopropyl alcohol / 0.08 h 3.2: 0.5 h View Scheme
参考文献
Babu, K. Srihari; Srinivas; Madhavi; Babu; Reddy, G. Madhusudhan; Haldar; Rao, P. Narasimha; Krishna; Venkateshwarulu; Reddy, P. Pratap; Anand, R. Vijaya
Arkivoc, 2011 , vol. 2011, # 2 p. 199 - 208
82410-32-0
更昔洛韦
+
598-31-2
溴丙酮
→
反应条件
134287-58-4
3-(1,3-二羟基丙-2-基氧基甲基)-6-甲基-5H-咪唑并[1,2-a]嘌呤-9-酮
反应条件
Yield given. Multistep reaction;
参考文献
Boryski; Golankiewicz; De Clercq
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2380 - 2383
1149-26-4
CBZ-L-缬氨酸
+
82410-32-0
更昔洛韦
→
反应条件
194154-40-0
Cbz-缬更昔洛韦
+
130914-77-1
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dimethyl sulfoxide T=18 - 30°C; 1 - 1.16667 h; Product distribution / selectivity;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/92891 A2, 2005 ;
Location in patent: Page/Page column 16-17; 21 ;
82410-32-0
更昔洛韦
→
反应条件
194154-40-0
Cbz-缬更昔洛韦
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dimethyl sulfoxide / 6.5 h / 18 - 28 °C 2.1: propylamine / methanol / 30 h / 27 °C 2.2: 12 - 20 °C View Scheme
参考文献
Katkam, Srinivas; Sagyam, Rajeswar Reddy; Ganta, Madhusudhan Reddy; Ireni, Babu; Korrothu, Srihari Babu; Morthala, Raghavendar Rao; Pagadala, Narsimha Rao; Kondepudi, Veera Venkata Satyanarayana Murthy
Patent: US2011/207931 A1, 2011 ;
82410-32-0
更昔洛韦
→
反应条件
86629-59-6
反应条件
1: 86 percent / 4-(dimethylamino)pyridine / 96 h / Ambient temperature 2: 38 percent / Et4N(+)*Cl(-), N,N-dimethylaniline, POCl3 / acetonitrile / 0.17 h / Heating 3: 86 percent / NH3 / methanol / 18 h / 90 °C View Scheme
参考文献
Martin; Jeffrey; McGee; Tippie; Smee; Matthews; Verheyden
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 358 - 362
82410-32-0
更昔洛韦
→
反应条件
89419-23-8
反应条件
1: 86 percent / 4-(dimethylamino)pyridine / 96 h / Ambient temperature 2: 38 percent / Et4N(+)*Cl(-), N,N-dimethylaniline, POCl3 / acetonitrile / 0.17 h / Heating 3: 86 percent / thiourea / propan-2-ol / 18 h / Heating 4: 73 percent / conc. NH4OH / methanol / 24 h / Ambient temperature 5: 38 percent / Raney Ni / H2O; ethanol / 24 h / Heating View Scheme
参考文献
Martin; Jeffrey; McGee; Tippie; Smee; Matthews; Verheyden
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 358 - 362
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