(E)-4’-羟基他莫昔芬合成路线 （共 5 条）
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF
2: 82 percent / 48percent aq. HBr, acetic acid / 4 h / Heating
3: 98percent H2SO4 / 12 h / Ambient temperature
4: 1.) C2H5MgBr, 3.) HCl
View Scheme
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
1: 85 percent / NaH, DMF / 3 h / 85 - 90 °C
2: 1.) C2H5MgBr, 3.) HCl
View Scheme
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
1: 82 percent / 48percent aq. HBr, acetic acid / 4 h / Heating
2: 98percent H2SO4 / 12 h / Ambient temperature
3: 1.) C2H5MgBr, 3.) HCl
View Scheme
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
1: 98percent H2SO4 / 12 h / Ambient temperature
2: 1.) C2H5MgBr, 3.) HCl
View Scheme
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
hydrogenchloride; ethylmagnesium bromide
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
