2,3-二氟-6-硝基苯酚合成路线 (共 13 条)
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol 3: 1 h / 140 - 145 °C 4: PPE / 1 h / 140 - 145 °C 5: 94 percent / conc. HCl / acetic acid / 3 h / Heating 6: 68 percent / dimethylsulfoxide / 5 h / 100 - 140 °C View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 65 percent / K2CO3, KI / acetone / 4 h / Heating 2: 90 percent / H2, Raney Ni / ethanol 3: 1 h / 140 - 145 °C 4: PPE / 1 h / 140 - 145 °C 5: 94 percent / conc. HCl / acetic acid / 3 h / Heating 6: 38 percent / dimethylsulfoxide / 1 h / 100 - 140 °C View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913
反应条件
1: 61 percent / K2CO3 / dimethylformamide / 2.5 h / 80 - 100 °C
2: 28 percent / sodium hydrosulfite / methanol; H2O / 1 h / Ambient temperature
3: 97 percent / K2CO3 / dimethylformamide / 1 h / 80 - 100 °C
4: 2.) PPE / 1.) 130-135 deg C, 2h; 2.) 140-145 deg C, 1.5h
5: 75 percent / conc. HCl / acetic acid / 4 h / 100 - 110 °C
6: 41 percent / dimethylsulfoxide / 6 h / 100 - 140 °C
View Scheme
参考文献
Hayakawa; Hiramitsu; Tanaka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 12 p. 4907 - 4913