2-氯-4,6-二甲氧基苯甲醛合成路线 （共 4 条）
反应条件
trichlorophosphate T=0 - 100°C; 2.5 h; Reflux;
参考文献
ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding
Patent: WO2011/17125 A1, 2011 ;
Location in patent: Page/Page column 113 ;
反应条件
trichlorophosphate T=40 - 50°C; Vilsmeier reaction;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1: 87 percent / hydrogen chloride gas / 25 - 30 °C 2: 92 percent / 1.) conc. hydrochloric acid, sodium nitrite, 2.) phosphinous acid / dioxane; H2O / 20 h / 0 °C 3: 2.0 g / phosphoryl chloride / 0 deg C; room temperature, 0.5 h; 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1095 - 1098
反应条件
1: 92 percent / 1.) conc. hydrochloric acid, sodium nitrite, 2.) phosphinous acid / dioxane; H2O / 20 h / 0 °C 2: 2.0 g / phosphoryl chloride / 0 deg C; room temperature, 0.5 h; 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1095 - 1098
