3-氯-5-甲氧基苯甲酸合成路线 （共 11 条）
反应条件
1: 3,5-dichloroanisole With magnesium; ethylene dibromide in tetrahydrofuran 2 h; Heating / reflux; 2: carbon dioxide in tetrahydrofuran
参考文献
ASTRAZENECA AB
Patent: WO2003/101956 A1, 2003 ;
Location in patent: Page 55 ;
WO 03/101956 A1
反应条件
1: With magnesium; ethylene dibromide in tetrahydrofuran 2 h; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Inghardt, Tord; Johansson, Anders; Svensson, Arne
Patent: US2004/19033 A1, 2004 ;
Location in patent: Page/Page column 21 ;
参考文献
Liu, Jiwen; Fu, Zice; Wang, Yingcai; Schmitt, Mike; Huang, Alan; Marshall, Derek; Tonn, George; Seitz, Lisa; Sullivan, Tim; Lucy Tang; Collins, Tassie; Medina, Julio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6419 - 6423
反应条件
1: With sodium methylate; tris-(dimethylamino)-phosphine T=170°C; 48 h; 2: With hydrogenchloride in water Product distribution / selectivity;
参考文献
US2008/293775 A1, ;
Page/Page column 25 ;
US 20080293775 A1
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; sodium methylate 15 h; Heating;
参考文献
Archiv der Pharmazie, , vol. 344, # 3 p. 197 - 204
反应条件
Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1095 - 1098
反应条件
aluminum oxide; iodine; tetra-(n-butyl)ammonium iodide in toluene 4 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2003/101956 A1, 2003 ;
Location in patent: Page 55; 56 ;
WO 03/101956 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
2 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
ASTRAZENECA AB
Patent: US2008/293775 A1, 2008 ;
Location in patent: Page/Page column 23; 25 ;
US 20080293775 A1
反应条件
1: SOCl2 / 4 h / Heating
2: 83 percent / diethyl ether; tetrahydrofuran / 1 h / -78 - 20 °C
View Scheme
参考文献
Hartmann; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
反应条件
thionyl chloride
4 h; Reflux;
参考文献
Liu, Jiwen; Fu, Zice; Wang, Yingcai; Schmitt, Mike; Huang, Alan; Marshall, Derek; Tonn, George; Seitz, Lisa; Sullivan, Tim; Lucy Tang; Collins, Tassie; Medina, Julio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6419 - 6423
