1: 90 percent / Oxone(R); NaHCO3 / 20 °C 2: H2 / Pd/C / methanol / 1.5 h 3: 57 mg / aq. HCl / 2.5 h / Heating View Scheme

1: H2 / Pd/C / methanol / 1.5 h 2: 57 mg / aq. HCl / 2.5 h / Heating View Scheme

1: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C 2: 90 percent / Oxone(R); NaHCO3 / 20 °C 3: H2 / Pd/C / methanol / 1.5 h 4: 57 mg / aq. HCl / 2.5 h / Heating View Scheme

1: 97 percent / K2CO3 / dimethylformamide / 2 h / 20 °C 2: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C 3: 90 percent / Oxone(R); NaHCO3 / 20 °C 4: H2 / Pd/C / methanol / 1.5 h 5: 57 mg / aq. HCl / 2.5 h / Heating View Scheme

1: 98 percent / aq. NaOH; aq.NaHCO3 / dioxane 2: 97 percent / K2CO3 / dimethylformamide / 2 h / 20 °C 3: 98 percent / TsOH*H2ODMF / toluene / 2 h / 115 °C 4: 90 percent / Oxone(R); NaHCO3 / 20 °C 5: H2 / Pd/C / methanol / 1.5 h 6: 57 mg / aq. HCl / 2.5 h / Heating View Scheme