(S)-(-)-N-[1-(羟甲基)-2-苯基乙基]-4-甲基苯磺酰胺合成路线 （共 16 条）
反应条件
1.1: sodium tetrahydroborate / ethanol; water / 4.5 h / Reflux 2.1: benzene / 0.17 h / 0 °C 2.2: 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 42, # 19 p. 2917 - 2930
反应条件
2: lithium aluminium tetrahydride View Scheme
参考文献
Molecules, , vol. 16, # 5 p. 3802 - 3825
反应条件
sodium azide; di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C; Mitsunobu reaction;
参考文献
Berggren, Kristina; Johansson, Bjoern; Fex, Tomas; Kihlberg, Jan; Bjoerck, Lars; Luthman, Kristina
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 9 p. 3463 - 3470
反应条件
1: p-toluenesulfonyl chloride, Et3N / CH2Cl2 / 12 h / Ambient temperature 2: 8 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C View Scheme
参考文献
Alonso, Diego A.; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9455 - 9461
反应条件
1: p-toluenesulfonyl chloride, Et3N / CH2Cl2 / 12 h / Ambient temperature 2: 47 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C View Scheme
参考文献
Alonso, Diego A.; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9455 - 9461
反应条件
1: p-toluenesulfonyl chloride, Et3N / CH2Cl2 / 12 h / Ambient temperature
2: 20 percent / Mg / methanol / 0.5 h / Ambient temperature
View Scheme
参考文献
Alonso, Diego A.; Andersson, Pher G.
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9455 - 9461
