((4-溴苄基)氧基)乙酸合成路线 （共 8 条）
反应条件
1: 4-bromobenzyl-alcohol With sodium hydride in tetrahydrofuran
T=0°C; 1 h;
2: monobromoacetic acid in tetrahydrofuran
3 h; Heating / reflux;
3: With hydrogenchloride; water
pH=2;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/76431 A1, 2007 ;
Location in patent: Page/Page column 224 ;
WO 2007/076431 A1
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 18 h;
参考文献
INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; CLARK, Ryan, Christopher; TRUONG, Yen, Pham
Patent: WO2013/134562 A1, 2013 ;
Location in patent: Paragraph 00165 ;
反应条件
potassium hydroxide in tetrahydrofuran
T=70°C; 1.5 h;
参考文献
Linn, Kathleen; Kuethe, Jeffrey T.; Peng, Zhihui; Yasuda, Nobuyoshi
Tetrahedron Letters, 2008 , vol. 49, # 23 p. 3762 - 3765
反应条件
sodium hydride in tetrahydrofuran
8 h; Heating;
参考文献
Abraham; Mehanna; Williams
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1015 - 1017
反应条件
sodium hydride in tetrahydrofuran
12 h; Heating;
参考文献
Abraham, D. J.; Kennedy, P. E.; Mehanna, A. S.; Patwa, D. C.; Williams, F. L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 967 - 978
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
View Scheme
参考文献
INCEPTION 2, INC.; STOCK, Nicholas, Simon; CHEN, Austin, Chih-Yu; BRAVO, Yalda, Mostofi; JACINTHO, Jason, Duarte; SCOTT, Jill, Melissa; STEARNS, Brian, Andrew; CLARK, Ryan, Christopher; TRUONG, Yen, Pham
Patent: WO2013/134562 A1, 2013 ;
反应条件
1: toluene
View Scheme
参考文献
Viout; Gault
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1953 , vol. 237, p. 1162
参考文献
Viout; Gault
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1953 , vol. 237, p. 1162
