3-甲氧基-4'-甲基二苯甲酮合成路线 （共 9 条）
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=20°C; 4 h; 2: With hydrogenchloride in dichloromethane; water
参考文献
NEUROSCIENZE PHARMANESS S.C. A.R.L.
Patent: US2011/152238 A1, 2011 ;
Location in patent: Page/Page column 48-49 ;
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=80°C; 3 h;
参考文献
Rao, Maddali L.N.; Venkatesh, Varadhachari; Banerjee, Debasis
Tetrahedron, 2007 , vol. 63, # 52 p. 12917 - 12926
反应条件
tri-tert-butyl phosphine; potassium carbonate; acetone; [Rh(C2H4)2Cl]2 in 1,4-dioxane; toluene T=20 - 80°C;
参考文献
Mora, Guilhem; Darses, Sylvain; Genet, Jean-Pierre
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 7 p. 1180 - 1184
反应条件
C57H43IP2Pd; potassium carbonate in 1,4-dioxane T=90°C; carbonylative Suzuki coupling; P=3750.38 Torr; 12 h; Autoclave;
参考文献
Kaganovsky, Luba; Gelman, Dmitri; Rueck-Braun, Karola
Journal of Organometallic Chemistry, 2010 , vol. 695, # 2 p. 260 - 266
反应条件
C57H43IP2Pd; potassium carbonate in 1,4-dioxane T=130°C; carbonylative Suzuki coupling; P=3750.38 Torr; 24 h; Autoclave;
参考文献
Kaganovsky, Luba; Gelman, Dmitri; Rueck-Braun, Karola
Journal of Organometallic Chemistry, 2010 , vol. 695, # 2 p. 260 - 266
反应条件
in various solvent(s) T=25°C; solvent: CF3SO3H; Rate constant;
参考文献
Tetrahedron, , vol. 39, # 1 p. 137 - 142
反应条件
1: 53 percent / KMnO4 / 2-methyl-propan-2-ol; H2O / 7.5 h / Heating 2: SOCl2 / benzene / 3 h / Heating 3: CHCl3 / 4 h / Ambient temperature 4: 70 percent / NaBH4 / ethanol; H2O / 2 h / Heating 5: 11.16 g / 37percent aq. HCl / CHCl3 / Ambient temperature View Scheme
参考文献
NEUROSCIENZE PHARMANESS S.C. A.R.L.
Patent: US2011/152238 A1, 2011 ;
反应条件
1: With potassium permanganate in water; tert-butyl alcohol 7.5 h; Reflux; 2: With sodium hydroxide in water 3: With hydrogenchloride in water
参考文献
Neuroscienze Pharmaness S.C. A R.L.
Patent: EP2338889 A1, 2011 ;
Location in patent: Page/Page column 69 ;
EP 2338889 A1
反应条件
1: 53 percent / KMnO4 / 2-methyl-propan-2-ol; H2O / 7.5 h / Heating
2: SOCl2 / benzene / 3 h / Heating
3: CHCl3 / 4 h / Ambient temperature
4: 70 percent / NaBH4 / ethanol; H2O / 2 h / Heating
5: 11.16 g / 37percent aq. HCl / CHCl3 / Ambient temperature
6: 29 percent / K2CO3 / acetonitrile / 72 h / Heating
View Scheme
参考文献
Calderon, Silvia N.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; McNutt, Robert W.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 14 p. 2125 - 2128
