3beta,5beta-二羟基开环屈螺酮醇合成路线 （共 3 条）
反应条件
1: With sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium hydrogencarbonate in dichloromethane; water T=15°C; pH=9.1; 2: With Na2S2O5 in dichloromethane; water T=15°C; 3: With sulfuric acid in dichloromethane; water T=25°C; pH=1; 0.5 h;
参考文献
Seilz, Carsten; Seba, Hartmut
Patent: US2007/21603 A1, 2007 ;
Location in patent: Page/Page column 6-7 ;
反应条件
IBX in dimethyl sulfoxide; N,N-dimethyl-formamide T=20 - 60°C; Product distribution / selectivity;
参考文献
INDUSTRIALE CHIMICA S.r.l.; LENNA, Roberto; BARBIERI, Francesco; GIUDICI, Daniele
Patent: EP2551275 A1, 2013 ;
Location in patent: Paragraph 0080-0083 ;
反应条件
1: 62 percent / pyridinium dichromate / dimethylformamide / 24 h / 70 °C
2: 59 percent / DDQ / dioxane / 1.5 h / 100 °C
View Scheme
参考文献
Bittler, Dieter; Hofmeister, Helmut; Laurent, Henry; Nickisch, Klaus; Petzoldt, Karl; et al.
Angewandte Chemie, 1982 , vol. 94, # 9 p. 718 - 719
