2,2-二甲基苯并二氢吡喃-8-羧酸合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
Metabolex, Inc.
Patent: US2011/313003 A1, 2011 ;
Location in patent: Page/Page column 26-27 ;
US 20110313003 A1
反应条件
1: 3,4-Dihydro-2,2-dimethyl-2H-1-benzopyran With n-butyllithium in hexanes; diethyl ether
1.5 h; Reflux;
2: carbon dioxide in hexanes; diethyl ether
T=20°C;
3: With water in hexanes; diethyl ether
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2010/80537 A1, 2010 ;
Location in patent: Page/Page column 61-62 ;
WO 2010/080537 A1
反应条件
n-butyllithium; diethyl ether
Behandeln der Reaktionsloesung mit festem Kohlendioxid;
参考文献
Hallet; Huls
Bulletin des Societes Chimiques Belges, 1952 , vol. 61, p. 33,39
反应条件
1.1: sulfuric acid; acetic acid / 0.75 h / 100 °C
2.1: n-butyllithium / diethyl ether; hexanes / 1.5 h / Reflux
2.2: 20 °C
View Scheme
参考文献
METABOLEX, INC.; SHI, Dong Fang; SONG, Jiangao; MA, Jingyuan; NOVACK, Aaron; PHAM, Phuongly; NASHASHIBI, Imad; RABBAT, Christopher J.; CHEN, Xin
Patent: WO2011/159297 A1, 2011 ;
WO 2011/159297 A1
