1: With n-butyllithium in tetrahydrofuran; hexane
T=-74 - -70°C; 1 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-70 - 15°C; 2 h;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
T=60°C; pH=1; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/2577 A1, 2005 ;
Location in patent: Page 224-225 ;
WO 2005/002577 A1
1: With toluene-4-sulfonic acid; ethylene glycol in toluene
Reflux;
2: With n-butyllithium; tri-isopropoxy-borane in diethyl ether
T=-78°C;
3: With hydrogenchloride in water
参考文献
El Abidine Chamas, Zein; Marchi, Enrico; Modelli, Alberto; Fort, Yves; Ceroni, Paola; Mamane, Victor
European Journal of Organic Chemistry, 2013 , # 12 p. 2316 - 2324
