Fmoc-L-4-碘苯丙氨酸合成路线 （共 4 条）
反应条件
potassium carbonate in 1,4-dioxane; water T=23°C; 16 h;
参考文献
Tetrahedron, , vol. 63, # 28 p. 6577 - 6586
反应条件
sodium carbonate in 1,4-dioxane 3 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1209 - 1213
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=0 - 25°C;
参考文献
Chemistry - A European Journal, , vol. 18, # 25 p. 7729 - 7737
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere 2.1: cadmium / N,N-dimethyl-formamide / 3.25 h / 20 °C / Inert atmosphere 2.2: 22 h / 20 °C 3.1: trifluoroacetic acid / dichloromethane / 20 °C 4.1: trimethylsilyl bromide / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere View Scheme
参考文献
Meyer, Christoph; Koehn, Maja
Synthesis, 2011 , # 20 art. no. T55011SS, p. 3255 - 3260
