(S)-1,2,3,4-四氢-6,7-二甲氧基-3-异喹啉羧酸盐酸盐合成路线 （共 8 条）
反应条件
hydrogenchloride in methanol; water T=60°C; 2 h;
参考文献
BRANTFORD CHEMICALS INC.
Patent: WO2003/101967 A1, 2003 ;
Location in patent: Page 16 ;
反应条件
1: 84 percent / Na2CO3 2: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 17 h 3: 94.8 percent / conc. HCl / H2O / 20 h / Heating 4: conc. HCl / H2O / 1) 3h, 90 deg C, 2) 0 deg C, 16h View Scheme
参考文献
Synthesis, , # 7 p. 550 - 556
反应条件
1: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 17 h 2: 94.8 percent / conc. HCl / H2O / 20 h / Heating 3: conc. HCl / H2O / 1) 3h, 90 deg C, 2) 0 deg C, 16h View Scheme
参考文献
Synthesis, , # 7 p. 550 - 556
反应条件
1: 68 percent / acetic anhydride / Heating 2: 84 percent / Na2CO3 3: H2 / <Rh(R-PROPHOS)(NBD)>PF6 / tetrahydrofuran / 17 h 4: 94.8 percent / conc. HCl / H2O / 20 h / Heating 5: conc. HCl / H2O / 1) 3h, 90 deg C, 2) 0 deg C, 16h View Scheme
参考文献
Synthesis, , # 7 p. 550 - 556
反应条件
1: 94.8 percent / conc. HCl / H2O / 20 h / Heating 2: conc. HCl / H2O / 1) 3h, 90 deg C, 2) 0 deg C, 16h View Scheme
参考文献
Synthesis, , # 7 p. 550 - 556
反应条件
hydrogenchloride; water Reflux;
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
反应条件
hydrogenchloride in water 1) 3h, 90 deg C, 2) 0 deg C, 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Synthesis, , # 7 p. 550 - 556
反应条件
1: dichloromethane / 20 °C 2: hydrogenchloride; water / Reflux View Scheme
参考文献
Chemical Communications, , vol. 47, # 38 p. 10746 - 10748
