1: 80 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating 2: 50percent aq. sulphuric acid / a. water removed, b. 130-140 deg C (15mm), 2h 3: 10percent aq. NaOH / Heating 4: 74.8 percent / 24 h / Heating View Scheme

1: 73.5 percent / piperidine acetate / toluene / 12 h / Heating 2: 80 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating 3: 50percent aq. sulphuric acid / a. water removed, b. 130-140 deg C (15mm), 2h 4: 10percent aq. NaOH / Heating 5: 74.8 percent / 24 h / Heating View Scheme

24 h; Heating;

1: 50percent aq. sulphuric acid / a. water removed, b. 130-140 deg C (15mm), 2h 2: 10percent aq. NaOH / Heating 3: 74.8 percent / 24 h / Heating View Scheme

1: POCl3 / toluene / 2 h / 95 °C 2: NaBH4 / methanol / Ambient temperature View Scheme