4-(2-吗啉乙氧基)苯甲醛合成路线 （共 8 条）
反应条件
1: 4-hydroxy-benzaldehyde With caesium carbonate in N,N-dimethyl-formamide T=20°C; 0.166667 h; 2: 2-(4-morpholino)ethyl chloride hydrochloride in N,N-dimethyl-formamide T=80°C;
参考文献
CELGENE CORPORATION; GANDHI, Anita; DIMARTINO, Jorge; CHOPRA, Rajesh
Patent: WO2014/39960 A1, 2014 ;
Location in patent: Page/Page column 66 ;
反应条件
in methanol; water T=20°C; 60 h;
参考文献
Nagarapu, Lingaiah; Aneesa; Satyender, Apuri; Chandana; Bantu, Rajaskaker
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 195 - 200
反应条件
1: N-(2-hydroxy-ethyl)-morpholine With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: 4-fluorobenzaldehyde in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Cho, Hoon; Wu, Ying; Choi, Cheol-Hee
Patent: US2011/269954 A1, 2011 ;
Location in patent: Page/Page column 6 ;
US 20110269954 A1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Substitution; Mitsunobu reaction; 24 h;
参考文献
MacChia, Bruno; Gentili, Daniela; MacChia, Marco; Mamone, Francesca; Martinelli, Adriano; Orlandini, Elisabetta; Rossello, Armando; Cercignani, Giovanni; Pierotti, Rita; Allegretti, Marcello; Asti, Cinzia; Caselli, Gianfranco
European Journal of Medicinal Chemistry, 2000 , vol. 35, # 1 p. 53 - 67
反应条件
potassium carbonate T=70°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 24 p. 7634 - 7640
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 104374/; Multistep reaction;
参考文献
Journal of the Chemical Society, , p. 4322 - 4330
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran Mitsunobu reaction;
参考文献
WO2004/7498 A2, ;
Page 20 ;
WO 2004/007498 A2
反应条件
lithium borohydride in tetrahydrofuran T=-60°C; 1 h;
参考文献
CELGENE CORPORATION; GANDHI, Anita; DIMARTINO, Jorge; CHOPRA, Rajesh
Patent: WO2014/39960 A1, 2014 ;
Location in patent: Page/Page column 66; 65 ;
