6-氯-2-(4-氯苯基)咪唑并[1,2-a]吡啶-3-乙酸合成路线 （共 11 条）
反应条件
water; potassium hydroxide in ethanol T=30°C;
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
potassium hydroxide in ethanol 8 h; Heating;
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1: methanol / 0.33 h / 30 °C 2: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1: methanol / 0.33 h / 30 °C 2: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 30 °C 2: pyridine / dichloromethane / 0.5 h / 0 °C 3: methanol / 0.33 h / 30 °C 4: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1: Br2, AcOH 2: 31 percent / butan-1-ol / Heating 3: aq. NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 19 p. 3109 - 3118
反应条件
1: 31 percent / butan-1-ol / Heating 2: aq. NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 19 p. 3109 - 3118
反应条件
1.1: 77 percent / acetic acid / H2O / 4 h / 50 - 55 °C 2.1: MeI / CH2Cl2 / 24 h / 20 °C 2.2: H2O / 4 h / Heating 3.1: 85 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 58, # 1 p. 43 - 52
反应条件
1.1: MeI / CH2Cl2 / 24 h / 20 °C 1.2: H2O / 4 h / Heating 2.1: 85 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 58, # 1 p. 43 - 52
反应条件
1: polymer supported sulfonic acid resin / toluene / 120 °C / |Flow reactor 2: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor 3: sodium hydroxide; water / ethanol / 90 °C / |Flow reactor View Scheme
参考文献
Chemical Science, , vol. 4, # 2 p. 764 - 769
