(4-丙烷-2-氧基苯基)甲醇合成路线 （共 7 条）
反应条件
1: With sodium tetrahydroborate in methanol
T=0 - 35°C; 4 h;
2: With hydrogenchloride; water in methanol
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1688138 A1, 2006 ;
Location in patent: Page/Page column 106 ;
EP 1688138 A1
反应条件
1: 4-hydroxymethyl-phenol With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: isopropyl bromide in N,N-dimethyl-formamide
18 h;
3: in N,N-dimethyl-formamide
pH=6.5; Aqueous phosphate buffer;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/91204 A1, 2003 ;
Location in patent: Page/Page column 59 ;
WO 03/091204 A1
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in toluene
2 h; Heating;
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
反应条件
1: 82 percent / K2CO3 / dimethylformamide / 18 h / 70 °C
2: 41 percent / Vitride / toluene / 2 h / Heating
View Scheme
参考文献
Kelley; Linn; Selway
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1757 - 1763
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1223170 A1, 2002 ;
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C
2: sodium tetrahydroborate / ethanol / 1 h / 20 °C
View Scheme
参考文献
Tangdenpaisal, Kassrin; Phakhodee, Wong; Ruchirawat, Somsak; Ploypradith, Poonsakdi
Tetrahedron, 2013 , vol. 69, # 2 p. 933 - 941
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Baddeley et al.
Journal of the Chemical Society, 1956 , p. 2455,246
Full Text Show Details
Tadros et al.
Journal of the Chemical Society, 1954 , p. 2351
