1-(溴甲基)-2-苯氧基苯合成路线 （共 6 条）
反应条件
phosphorus tribromide in dichloromethane T=5 - 20°C;
参考文献
SANOFI-AVENTIS
Patent: US2011/178134 A1, 2011 ;
Location in patent: Page/Page column 48 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 4 h; Reflux;
参考文献
Gobbi, Silvia; Zimmer, Christina; Belluti, Federica; Rampa, Angela; Hartmann, Rolf W.; Recanatini, Maurizio; Bisi, Alessandra
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5347 - 5351
反应条件
1: tetrahydrofuran; methanol; n-heptane; ethyl acetate 2: phosphorus tribromide; anhydrous sodium hydrogen carbonate / 1,4-dioxane; n-heptane; water; ethyl acetate View Scheme
反应条件
1: thionyl chloride / methanol 2: tetrahydrofuran; methanol; n-heptane; ethyl acetate 3: phosphorus tribromide; anhydrous sodium hydrogen carbonate / 1,4-dioxane; n-heptane; water; ethyl acetate View Scheme
反应条件
hydrogenchloride; ethanol; sodium iodide
参考文献
Ito
Pharmaceutical Bulletin, 1957 , vol. 5, p. 397,399
反应条件
chloroform beim Erhitzen des Reaktionsprodukts mit wss. Essigsaeure und anschliessend mit wss.HCl;
参考文献
Pharmaceutical Bulletin, , vol. 5, p. 397,399
