2,3-二氢-5,6-二甲氧基-N,N-二丙基-1H-茚-2-胺合成路线 （共 8 条）
反应条件
triethylsilane; boron trifluoride diethyl etherate in 1,2-dichloro-ethane
T=83°C; 1.5 h;
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: 95 percent / n-butylnitrite; conc. aq. HCl / methanol / 0.5 h / 40 °C
2: H2; H2SO4 / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr
3: 2.04 g / sodium triacetoxyborohydride; Et3N / 1,2-dichloro-ethane / 24 h
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: H2; H2SO4 / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr
2: 2.04 g / sodium triacetoxyborohydride; Et3N / 1,2-dichloro-ethane / 24 h
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: 40.2 g / AlCl3 / CH2Cl2 / 3 h / 20 °C
2: 95 percent / n-butylnitrite; conc. aq. HCl / methanol / 0.5 h / 40 °C
3: H2; H2SO4 / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr
4: 2.04 g / sodium triacetoxyborohydride; Et3N / 1,2-dichloro-ethane / 24 h
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: 26.32 g / sodium triacetoxyborohydride / tetrahydrofuran / 23 h / 20 °C
2: 91 percent / Et3SiH; BF3*OEt2 / 1,2-dichloro-ethane / 1.5 h / 83 °C
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
1: BH3*Me2S / tetrahydrofuran / 0.5 h
2: 26.32 g / sodium triacetoxyborohydride / tetrahydrofuran / 23 h / 20 °C
3: 91 percent / Et3SiH; BF3*OEt2 / 1,2-dichloro-ethane / 1.5 h / 83 °C
View Scheme
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
sodium tris(acetoxy)borohydride; triethylamine in 1,2-dichloro-ethane
24 h;
参考文献
Haadsma-Svensson; Cleek; Dinh; Duncan; Haber; Huff; Lajiness; Nichols; Smith; Svensson; Zaya; Carlsson; Lin
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4716 - 4732
反应条件
sodium tetrahydroborate
1.) benzene, from 10 to 20 deg C, 2.) benzene, reflux, 20 h; Multistep reaction;
参考文献
Cannon, Joseph G.; Perez, Julio A.; Bhatnagar, Rambir K.; Long, John Paul; Sharabi, Fouad M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1442 - 1446
