2,6-二氯-5-氟烟酸合成路线

82671-06-52,6-二氯-5-氟烟酸

791644-48-92-氯-5-氟烟腈

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/20377 A1, 2011 ;
US 20110020377 A1

82671-06-52,6-二氯-5-氟烟酸

82671-03-22,6-二氯-5-氟吡啶-3-羧酸乙酯

参考文献

Abbott Laboratories
Patent: US5250548 A1, 1993 ;
US 5250548 A

541-41-3氯甲酸乙酯+

82671-06-52,6-二氯-5-氟烟酸

82671-03-22,6-二氯-5-氟吡啶-3-羧酸乙酯

参考文献

DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1640366 A1, 2006 ;
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82671-06-52,6-二氯-5-氟烟酸

96568-02-42,6-二氯-5-氟代烟酰氯

参考文献

ASTRAZENECA AB
Patent: WO2008/85119 A1, 2008 ;
Location in patent: Page/Page column 209 ;
WO 2008/085119 A1

82671-06-52,6-二氯-5-氟烟酸

96568-04-62,6-二氯-5-氟烟酰乙酸乙酯

参考文献

Bouzard, D.; Cesare, P. Di; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 518 - 525

82671-06-52,6-二氯-5-氟烟酸

96568-07-9环丙基萘啶羧酸乙酯

参考文献

Bouzard, D.; Cesare, P. Di; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 518 - 525

82671-06-52,6-二氯-5-氟烟酸+

74-88-4甲基碘

132195-42-72,6-二氯-5-氟-4-甲基吡啶-3-羧酸+

132195-49-4

参考文献

Anderson, David; Beutel, Bruce; Bosse, Todd D.; Clark, Richard; Cooper, Curt; Dandliker, Peter; David, Caroline; Gu, Yu-Gui; Hansen, Todd Matthew; Hinman, Mira; Kalvin, Douglas; Larson, Daniel P.; Lynch, Linda; Ma, Zhenkun; Motter, Christopher; Palazzo, Fabio; Rosenberg, Teresa; Rehm, Tamara; Sanders, William; Tufano, Michael; Wagner, Rolf; Weitzberg, Moshe; Yong, Hong; Zhang, Tianyuan
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Location in patent: Page 36 ;

82671-06-52,6-二氯-5-氟烟酸+

74-88-4甲基碘

132195-42-72,6-二氯-5-氟-4-甲基吡啶-3-羧酸

参考文献

Bouzard, D.; Cesare, P. Di; Essiz, M.; Jacquet, J. P.; Ledoussal, B.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 518 - 525

82671-06-52,6-二氯-5-氟烟酸

100491-63-21-(2,4-二氟苯基)-6-氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯

参考文献

Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369

82671-06-52,6-二氯-5-氟烟酸

100546-84-76-氟-1-(4-氟苯基)-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯

参考文献

Chu, Daniel T. W.; Fernandes, Prabhavathi B.; Claiborne, Akiyo K.; Gracey, Eugene H.; Pernet, Andre G.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2364 - 2369