2,6-二氯-5-氟烟酸合成路线 （共 34 条）
反应条件
1.1: triethylamine; formic acid / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C
2.2: 0 - 20 °C
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参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2011/20377 A1, 2011 ;
US 20110020377 A1
反应条件
borane dimethyl sulfide complex in tetrahydrofuran
3 h; Heating / reflux;
参考文献
Gavai, Ashvinikumar V.; Norris, Derek J.; Han, Wen-Ching; Vite, Gregory D.; Fink, Brian E.; Tokarski, John S.
Patent: US2005/192310 A1, 2005 ;
Location in patent: Page/Page column 20 ;
反应条件
1: With sodium hydroxide in water
T=20°C; 18 h; Heating / reflux;
2: With hydrogenchloride in water
T=0°C; 0.5 h;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/44084 A2, 2007 ;
Location in patent: Page/Page column 134 ;
WO 2007/044084 A2
反应条件
1: in methanol
4 h; Heating / reflux;
2: With hydrogenchloride; water in methanol
pH=2;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/128962 A1, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/128962 A1
