1: With potassium tert-butylate; copper (II) acetate monohydrate; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride; tert-butyl alcohol in toluene T=25°C; 25 h; Neutral conditions; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran; toluene T=0°C; diastereoselective reaction;

sodium tetrahydroborate; hydrogen; nickel diacetate; ethylenediamine Inert atmosphere; stereoselective reaction;