lithium hydroxide in tetrahydrofuran; water T=20°C;

1.1: lithium diisopropyl amide (DLA) / tetrahydrofuran / -75 °C 1.2: 63 percent / tetrahydrofuran / -75 - 20 °C 2.1: 49 percent / Et3N / acetonitrile / 20 °C 3.1: 100 percent / LiOH / tetrahydrofuran; H2O / 20 °C View Scheme

1: 49 percent / Et3N / acetonitrile / 20 °C 2: 100 percent / LiOH / tetrahydrofuran; H2O / 20 °C View Scheme