lithium hydroxide in tetrahydrofuran; water T=20°C;

1.2: lithium 2,2,6,6-tetramethylpiperidine 2.1: Bu4NF / tetrahydrofuran / 12 h / 20 °C 3.1: 76 percent / Et3N / acetonitrile 4.1: 100 percent / LiOH / tetrahydrofuran; H2O / 20 °C View Scheme