4-溴-5-氯-2-硝基苯胺合成路线 （共 6 条）
反应条件
N-bromosuccinmide in acetic acid 0.75 h; Reflux;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; BAeRFACKER, Lars; KAST, Raimund; GRIEBENOW, Nils; MEIER, Heinrich; KOLKHOF, Peter; ALBRECHT-KUePPER, Barbara; NITSCHE, Adam; STASCH, Johannes-Peter; SCHNEIDER, Dirk; TEUSCH, Nicole; RUDOLPH, Joachim; WHELAN, James; BULLOCK, William; PLEASIC-WILLIAMS, Susan
Patent: WO2010/20363 A1, 2010 ;
Location in patent: Page/Page column 78-79 ;
反应条件
potassium carbonate in methanol T=20°C; 10 h;
参考文献
US2007/259936 A1, ;
Page/Page column 176 ;
US 20070259936 A1
反应条件
sulfuric acid in water 2.5 h; Heating;
参考文献
Britton, Doyle; Noland, Wayland E.; Pinnow, Matthew J.; Young Jr., Victor G.
Helvetica Chimica Acta, 2003 , vol. 86, # 4 p. 1175 - 1192
反应条件
Nitrierung; man verseift das entstandene Acetylderivat durch Kochen mit Alkohol + konz.Salzsaeure;
参考文献
American Chemical Journal, , vol. 22, p. 273
反应条件
1.1: conc. HCl / H2O / 0.33 h / 20 °C 1.2: 88 percent / AcONa / H2O / 0.5 h 2.1: 46 percent / KNO3 / H2SO4 / 0.33 h / 20 °C 3.1: 93 percent / H2SO4 / H2O / 2.5 h / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 4 p. 1175 - 1192
反应条件
1: glacial acetic acid; bromine 2: Nitrierung; man verseift das entstandene Acetylderivat durch Kochen mit Alkohol + konz.Salzsaeure View Scheme
参考文献
American Chemical Journal, , vol. 22, p. 273
