5-氯-3-苯基-1,2,4-恶二唑合成路线 （共 7 条）
反应条件
hydroxylamine hydrochloride in sulfolane
参考文献
Synthesis, , p. 599 - 605
参考文献
Bulletin de la Societe Chimique de France, , p. 1219 - 1220
参考文献
Yakugaku Zasshi, , vol. 84, p. 1061,1066
Chem.Abstr., , vol. 62, # 5270
参考文献
Yakugaku Zasshi, , vol. 84, p. 1061,1066
Chem.Abstr., , vol. 62, # 5270
反应条件
ammonia in methanol
P=760.051 Torr; Inert atmosphere;
参考文献
PORTOLA PHARMACEUTICALS, INC.; SONG, Yonghong; XU, Qing; SRAN, Arvinder; BAUER, Shawn M.; JIA, Zhaozhong J.; KANE, Brian; PANDEY, Anjali
Patent: WO2013/192046 A2, 2013 ;
Location in patent: Paragraph 0188 ;
反应条件
1: 84 percent / benzene / 1 h / Ambient temperature
2: 75 percent / 1 h / Heating
3: 51 percent / borane / tetrahydrofuran
View Scheme
参考文献
Adembri, Giorgio; Camparini, Alfredo; Ponticelli, Fabio; Tedeschi, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1703 - 1706
反应条件
1: 90 percent / hydrazine / dioxane / 1 h / Ambient temperature
2: hydrogen / 10percent Pd-charcoal
3: 76 percent / hydroxylamine-O-sulphonic acid, 1M sodium hydroxide / H2O / 30 h / Ambient temperature
4: 27 percent / methanol; diethyl ether
5: 75 percent / sodium nitrite, 6M hydrochloric acid / H2O
View Scheme
参考文献
Adembri, Giorgio; Camparini, Alfredo; Ponticelli, Fabio; Tedeschi, Piero
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 1703 - 1706
