3-氯苯甲亚氨酸乙酯盐酸盐(1:1)合成路线 （共 3 条）
反应条件
ammonia in ethanol T=20°C;
参考文献
TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei
Patent: WO2014/66659 A1, 2014 ;
Location in patent: Paragraph 0556 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 48 h;
参考文献
TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei
Patent: WO2014/66659 A1, 2014 ;
Location in patent: Paragraph 0555 ;
反应条件
1: polyphosphoric acid / chlorobenzene / 24 h / Heating
2: POCl3, N,N-dimethylanilin / 4.5 h / Heating
3: 2 h / Heating
View Scheme
参考文献
Haubold; Pech; Bernath; et al.
Pharmazie, 1983 , vol. 38, # 4 p. 269 - 270
