3-(4-硝基-1-氧代-1,3-二氢异吲哚-2-基)哌啶-2,6-二酮合成路线 （共 11 条）
反应条件
1: With sodium carbonate in acetonitrile T=5°C; Inert atmosphereRefluxLarge scale; 2: With hydrogenchloride in water T=20 - 62°C; pH=< 6; 4 h; Large scale;
参考文献
CELGENE CORPORATION; LI, Ying; XU, Jean; KLOPFER, Kevin, J.
Patent: WO2013/126394 A1, 2013 ;
Location in patent: Paragraph 00123-00125 ;
反应条件
thionyl chloride in N,N-dimethyl-formamide T=0°C;
参考文献
NANJING CAVENDISH BIO-ENGINEERING TECHNOLOGY CO., LTD.; YAN, Rong; YANG, Hao; XU, Yongxiang
Patent: WO2010/139266 A1, 2010 ;
Location in patent: Page/Page column 55 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 45°C; Product distribution / selectivity;
参考文献
RANBAXY LABORATORIES LIMITED; KAPOOR, Munish; KUMAR, Saridi, Madhava, Dileep; MURUGESAN, Balaguru; SATHYANARAYANA, Swargam; THAPER, Rajesh, Kumar; PRASAD, Mohan
Patent: WO2011/27326 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
potassium carbonate in N,N-dimethyl acetamide T=20 - 50°C; 40.5 h; Inert atmosphere;
参考文献
Greig, Nigel H.; Luo, Weiming; Tweedie, David; Holloway, Harold W.; Yu, Qian-Sheng; Goetzl, Edward J.
Patent: US2013/143922 A1, 2013 ;
Location in patent: Paragraph 0085; 0086 ;
反应条件
1: 3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine With palladium 10 on activated carbon; hydrogen in methanol T=25 - 35°C; 2 h; 2: 2-(bromomethyl)-3-nitrobenzoic acid,methyl ester With triethylamine in N,N-dimethyl-formamide T=25 - 35°C; 6 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2013/5229 A1, 2013 ;
Location in patent: Page/Page column 8 ;
反应条件
1: NBS / CCl4 / Heating; Irradiation 2: Et3N / dimethylformamide / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 11 p. 1625 - 1630
反应条件
1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: Et3N / dimethylformamide / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 11 p. 1625 - 1630
反应条件
1: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 2: Et3N / dimethylformamide / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 11 p. 1625 - 1630
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h / Reflux 2.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / methanol / 23 h / 760.05 Torr 3.1: acetonitrile / 0.25 h / 20 °C 3.2: 7 h / 20 °C / Reflux View Scheme
反应条件
formamide T=160 - 170°C; Product distribution / selectivity;
参考文献
WO2005/5409 A1, ;
Page/Page column 7 ;
