4-氯-5,6-二甲基-7h-吡咯并[2,3-d]嘧啶合成路线 （共 13 条）
反应条件
aluminium trichloride in toluene
2 h; Heating;
参考文献
Traxler, Peter M.; Furet, Pascal; Mett, Helmut; Buchdunger, Elisabeth; Meyer, Thomas; Lydon, Nicholas
Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2285 - 2292
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
反应条件
1: 60 percent / 5 h / 110 °C
2: 76 percent / POCl3 / 2.5 h / Heating
3: AlCl3 / toluene / 2 h / Heating
View Scheme
参考文献
Traxler, Peter M.; Furet, Pascal; Mett, Helmut; Buchdunger, Elisabeth; Meyer, Thomas; Lydon, Nicholas
Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2285 - 2292
反应条件
1: 76 percent / POCl3 / 2.5 h / Heating
2: AlCl3 / toluene / 2 h / Heating
View Scheme
参考文献
Traxler, Peter M.; Furet, Pascal; Mett, Helmut; Buchdunger, Elisabeth; Meyer, Thomas; Lydon, Nicholas
Journal of Medicinal Chemistry, 1996 , vol. 39, # 12 p. 2285 - 2292
反应条件
trichlorophosphate
1.5 h; Heating;
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
反应条件
1: 55.2 percent / polyphosphoric acid / 4 h / 60 °C
2: 53.1 percent / POCl3 / 1.5 h / Heating
View Scheme
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
反应条件
1: 55.2 percent / polyphosphoric acid / 1.5 h / 60 °C
2: 53.1 percent / POCl3 / 1.5 h / Heating
View Scheme
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
反应条件
1: 98.3 percent / 8 h / Heating
2: 55.2 percent / polyphosphoric acid / 1.5 h / 60 °C
3: 53.1 percent / POCl3 / 1.5 h / Heating
View Scheme
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
反应条件
1: 84.5 percent / 8 h / Heating
2: 55.2 percent / orthophosphoric acid / 4 h / 60 - 80 °C
3: 53.1 percent / POCl3 / 1.5 h / Heating
View Scheme
参考文献
Pichler, Herbert; Folkers, Gerd; Roth, Hermann J.; Eger, Kurt
Liebigs Annalen der Chemie, 1986 , # 9 p. 1485 - 1505
