tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 2 h;

1.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C 1.2: Pd(PPh3)4 / tetrahydrofuran / 12 h / 20 °C 2.1: 76 percent / n-Bu4NF / tetrahydrofuran / 2 h / 0 °C View Scheme

1.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / 20 °C 1.2: Pd(PPh3)4 / tetrahydrofuran / 12 h / 20 °C 2.1: 76 percent / n-Bu4NF / tetrahydrofuran / 2 h / 0 °C View Scheme