1: octahydroindole-2-carboxylic acid benzyl ester hydrochloride With sodium hydroxide in dichloromethane; water 1 h; 2: N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride With triethylamine in dichloromethane T=20°C; 3 h; 3: With hydrogen; palladium 10 on activated carbon in ethanol P=1500.15 Torr; Product distribution / selectivity;

1: With sodium hydroxide in water 1 h; 2: With (2R,3S)-(-)-di-O-benzoyl tartaric acid in methanol 1 h; Resolution of racemate; 3: With hydrogenchloride; sodium hydroxide more than 3 stages;