1: 3,4,5-trimethoxythiophenol With potassium carbonate in N,N-dimethyl-formamide T=20°C; 1 h; 2: 8-Bromo-Adenine in N,N-dimethyl-formamide T=90°C; 14 h;

1.1: bromine / H2O / 20 °C 2.1: K2CO3 / dimethylformamide / 1 h / 20 °C 2.2: dimethylformamide / 14 h / 90 °C View Scheme

1.1: aq. HCl; NaNO2 / 0 °C 1.2: 58 percent / H2O / 0.67 h / 50 °C 2.1: 1.18 g / LiAlH4 / tetrahydrofuran / 1 h / Heating 3.1: K2CO3 / dimethylformamide / 1 h / 20 °C 3.2: dimethylformamide / 14 h / 90 °C View Scheme

1.1: 1.18 g / LiAlH4 / tetrahydrofuran / 1 h / Heating 2.1: K2CO3 / dimethylformamide / 1 h / 20 °C 2.2: dimethylformamide / 14 h / 90 °C View Scheme