(4R)-4-甲基-4-[(E)-2-(3-甲基-2-噻吩基)乙烯基]-1,3-恶唑烷-2-酮合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; methanol; water
1.5 h;
2: With potassium tert-butylate in tetrahydrofuran
0.833333 h;
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
反应条件
1.1: potassium tert-butoxide / tetrahydrofuran / 0.33 h / 20 °C
1.2: tetrahydrofuran / 0.5 h / cooling
2.1: NaOH / methanol; tetrahydrofuran; H2O / 1.5 h
2.2: potassium tert-butoxide / tetrahydrofuran / 0.83 h
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
反应条件
1.1: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 20 °C
2.1: potassium tert-butoxide / tetrahydrofuran / 0.33 h / 20 °C
2.2: tetrahydrofuran / 0.5 h / cooling
3.1: NaOH / methanol; tetrahydrofuran; H2O / 1.5 h
3.2: potassium tert-butoxide / tetrahydrofuran / 0.83 h
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
反应条件
1.1: TOYOBO / diisopropyl ether / 2 h / 20 °C
2.1: pyridinium chlorochromate; molecular sieves 4 Angstroem / CH2Cl2 / 2 h / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 0.33 h / 20 °C
3.2: tetrahydrofuran / 0.5 h / cooling
4.1: NaOH / methanol; tetrahydrofuran; H2O / 1.5 h
4.2: potassium tert-butoxide / tetrahydrofuran / 0.83 h
View Scheme
参考文献
Nakamura, Tsuyoshi; Tsuji, Takashi; Iio, Yukiko; Miyazaki, Shojiro; Takemoto, Toshiyasu; Nishi, Takahide
Tetrahedron Asymmetry, 2006 , vol. 17, # 19 p. 2781 - 2792
