(6-氨基吡啶-3-基)-吗啉-4-基甲酮合成路线 (共 1 条)
反应条件
1: 2-amino-5-pyridine carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=20°C; 1.5 h;
2: morpholine With pyridine in dichloromethane
T=0 - 20°C;
3: With ethylenediamine in ethanol; dichloromethane
0.5 h; Reflux;
参考文献
MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.
Patent: WO2014/52365 A1, 2014 ;
Location in patent: Page/Page column 173 ;