6-氨基-N,N-二甲基-烟酰胺合成路线 （共 3 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; ethyl acetate
T=25°C; 17 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BROTHERTON-PLEISS, Christine; JAIME-FIGUEROA, Saul; LOPEZ-TAPIA, Francisco Javier; LOU, Yan; OWENS, Timothy D.
Patent: WO2013/24078 A1, 2013 ;
Location in patent: Page/Page column 69 ;
反应条件
1: sodium azide / N,N-dimethyl-formamide / 60 h / 120 °C
2: hydrogen / palladium 10 on activated carbon / ethyl acetate; methanol / 17 h / 25 °C
View Scheme
参考文献
Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael
Patent: US2012/40949 A1, 2012 ;
US 20120040949 A1
反应条件
1: tetrahydrofuran; dichloromethane / 3.25 h / |Inert atmosphere
2: sodium azide / N,N-dimethyl-formamide / 60 h / 120 °C
3: hydrogen; palladium 10 on activated carbon / ethyl acetate; methanol / 17 h / 25 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BROTHERTON-PLEISS, Christine; JAIME-FIGUEROA, Saul; LOPEZ-TAPIA, Francisco Javier; LOU, Yan; OWENS, Timothy D.
Patent: WO2013/24078 A1, 2013 ;
