4-(4'-溴(1,1'-联苯)-4-基)-2,4-二氧代丁酸合成路线 （共 2 条）
反应条件
sodium hydroxide in 1,4-dioxane; ethanol
Ambient temperature;
参考文献
Williams, H. W. R.; Eichler, E.; Randall, W. C.; Rooney, C. S.; Cragoe, E. J.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1196 - 1200
反应条件
1: 47.3 percent / NaOCH3 / benzene / 1.) 5 deg C, 0.5 h, 2.) RT, 2 h
2: 17.5 percent / 2 N aq. NaOH / ethanol; dioxane / Ambient temperature
View Scheme
参考文献
Williams, H. W. R.; Eichler, E.; Randall, W. C.; Rooney, C. S.; Cragoe, E. J.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1196 - 1200
