4H-噻吩并[3,2-b]吡咯-5-羧酸甲酯合成路线 （共 8 条）
反应条件
1: in methanol; hexanes T=0°C; 0.166667 h; 2: With water; acetic acid
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 40 ;
反应条件
in toluene 3 h; Heating;
参考文献
Yarovenko; Semenov; Zavarzin; Ignatenko; Krayushkin
Russian Chemical Bulletin, 2003 , vol. 52, # 2 p. 451 - 456
反应条件
1: 48 percent / sodium methoxide / methanol / 4 h / -10 °C 2: 84 percent / Rh2(pbf)4 / toluene / 16 h / 60 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 129, # 24 p. 7500 - 7501
反应条件
in toluene Hemetsberger-Knittel reaction; 2 h; Reflux;
参考文献
Srinivasan, Selvi; Schuster, Gary B.
Organic Letters, 2008 , vol. 10, # 17 p. 3657 - 3660
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
Sindac, Janice A.; Yestrepsky, Bryan D.; Barraza, Scott J.; Bolduc, Kyle L.; Blakely, Pennelope K.; Keep, Richard F.; Irani, David N.; Miller, David J.; Larsen, Scott D.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3535 - 3545
反应条件
1: dimethylformamide / 60 °C 2: AcOH / 120 °C 3: K2CO3 / dimethylformamide / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 21 p. 5567 - 5571
参考文献
Organic Letters, , vol. 4, # 22 p. 3879 - 3881
反应条件
potassium hydroxide; water in tetrahydrofuran 10 h; Reflux;
参考文献
Srinivasan, Selvi; Schuster, Gary B.
Organic Letters, 2008 , vol. 10, # 17 p. 3657 - 3660
