甲基6-甲基-1-苯并噻吩-2-羧酸酯合成路线 （共 3 条）
反应条件
sodium hydride
1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min; Yield given. Multistep reaction;
参考文献
Bridges, Alexander J.; Lee, Arthur; Maduakor, Emmanuel C.; Eric Schwartz
Tetrahedron Letters, 1992 , vol. 33, # 49 p. 7499 - 7502
反应条件
hydrogenchloride
3 h; Heating;
参考文献
Cross; Dickinson; Parry; Randall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1637 - 1643
反应条件
1: 1.) s-BuLi, N,N,N',N'-tetramethylethylenediamine (TMEDA) / 1.) hexane, THF, -78 deg C, 2.) -78 deg C
2: 1.) NaH / 1.) DMSO, 20 deg C, 2.) DMSO, 2-5 min
View Scheme
参考文献
Bridges, Alexander J.; Lee, Arthur; Maduakor, Emmanuel C.; Eric Schwartz
Tetrahedron Letters, 1992 , vol. 33, # 49 p. 7499 - 7502
