DL-3-苯基-2-羟丙酸合成路线 （共 84 条）
反应条件
sodium hydroxide; sodium tetrahydroborate T=5 - 10°C;
参考文献
Baskar; Pandian; Priya; Chadha, Anju
Tetrahedron, 2005 , vol. 61, # 52 p. 12296 - 12306
反应条件
potassium hydroxide in water
参考文献
Chow, Yuan L.; Polo, Joel
Journal of the Chemical Society, Chemical Communications, 1981 , # 6 p. 297 - 299
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Dahn, Hans; Rotzler, Gerhard
Journal of Organic Chemistry, 1991 , vol. 56, p. 3080 - 3082
反应条件
1: With NADH; nicotinamide adenine dinucleotide T=30°C; pH=7; aq. potassium phosphate bufferInert atmosphereEnzymatic reaction; 2: With hydrogenchloride in water aq. potassium phosphate buffer;
参考文献
Tetrahedron, , vol. 65, # 36 p. 7752 - 7755
参考文献
Journal of the American Chemical Society, , vol. 87, p. 4588 - 4592
反应条件
1: 95 percent / 2N aq. Na2CO3 / dioxane / 0.5 h / Ambient temperature 2: 89 percent / 2N HCl / 1 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, p. 3080 - 3082
反应条件
1: aq. KOH 2: aq. NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 87, p. 4588 - 4592
反应条件
1.1: sodium hydrogensulfite / water / 0.5 h / 0 °C 1.2: 1.75 h / 5 - 10 °C 2.1: water; hydrogenchloride / 1 h / 95 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 4 p. 559 - 570
反应条件
1: AD-mix α / 2-methyl-propan-2-ol; H2O / 20 °C 2: 100 percent / Et3N; DMAP / CH2Cl2 3: 52 percent / DIPEA / CH2Cl2 4: 86 percent / TBAF / tetrahydrofuran 5: 89 percent / TEMPO; NAOCl; NaOCl2 / aq. phosphate buffer; acetonitrile / 55 °C / pH 6.5 6: 89 percent / ZnBr2 / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 17 p. 3209 - 3213
反应条件
1: 52 percent / DIPEA / CH2Cl2 2: 86 percent / TBAF / tetrahydrofuran 3: 89 percent / TEMPO; NAOCl; NaOCl2 / aq. phosphate buffer; acetonitrile / 55 °C / pH 6.5 4: 89 percent / ZnBr2 / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 17 p. 3209 - 3213
