BOC-PHE-PHE-GLY-OH合成路线 （共 14 条）
反应条件
1: 81 percent / 1.) triethylamine (TEA), 2.) N-hydroxybenztriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / dimethylformamide / 16 h
2: 82 percent / 1 M NaOH / methanol; H2O / 1 h / 0 °C
View Scheme
参考文献
Lipkowski, Andrzej W.; Misicka, Aleksandra; Drabarek, Stefania
Polish Journal of Chemistry, 1981 , vol. 55, # 4 p. 813 - 818
反应条件
hydrogenchloride; triethylamine; sodium nitrite
1.) glacial acetic acid, 0 deg C, 15 min, 2.) DMF, 0 deg C, 6 d; Yield given. Multistep reaction;
参考文献
Koziolkiewicz, Wiktor; Wasiak, Tadeusz; Janecka, Anna
Polish Journal of Chemistry, 1985 , vol. 59, # 7-9 p. 819 - 826
反应条件
1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
2: TFA, anisole / CH2Cl2 / 1 h / 0 °C
3: 55 percent
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
反应条件
1: 54.6 percent / IBCF, NMMole / dimethylformamide / -20 °C
2: TFA, anisole / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Michelot; Mayer; Magneney; Pham Van Chuong; Schmitt; Potier
European Journal of Medicinal Chemistry, 1988 , vol. 23, # 3 p. 243 - 247
