in DMF (N,N-dimethyl-formamide) T=20 - 100°C; 16.5833 h;

1: N,N-dimethyl acetamide With trichlorophosphate in acetonitrile T=10 - 20°C; 0.1 h; Inert atmosphereLarge scale; 2: 2-[(3-aminobenzyl)(methyl)amino]-6,7-dimethoxy-5-methyl-1H-quinazolin-4-one in dichloromethane; acetonitrile T=0.2°C; 0.1 h; Inert atmosphereLarge scale;

1.1: potassium hydroxide / tetrahydrofuran; water / 18 h / 20 - 25 °C / |Inert atmosphere; |Large scale 2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / |Inert atmosphere; |Reflux; |Large scale 3.1: palladium 10 on activated carbon; sodium hydroxide; hydrogen / tetrahydrofuran; methanol / 2.5 h / 22 °C / |Large scale 4.1: trichlorophosphate / acetonitrile / 0.1 h / 10 - 20 °C / |Inert atmosphere; |Large scale 4.2: 0.1 h / 0.2 °C / |Inert atmosphere; |Large scale View Scheme

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 24 h / |Inert atmosphere; |Reflux; |Large scale 2.1: palladium 10 on activated carbon; sodium hydroxide; hydrogen / tetrahydrofuran; methanol / 2.5 h / 22 °C / |Large scale 3.1: trichlorophosphate / acetonitrile / 0.1 h / 10 - 20 °C / |Inert atmosphere; |Large scale 3.2: 0.1 h / 0.2 °C / |Inert atmosphere; |Large scale View Scheme