5-硝基-1(2H)-异喹啉酮合成路线 （共 9 条）
参考文献
Rehwinkel, Hartmut; Baeurle, Stefan; Berger, Markus; Schmees, Norbert; Schaecke, Heike; Krolikiewicz, Konrad; Mengel, Anne; Nguyen, Duy; Jaroch, Stefan; Skuballa, Werner
Patent: US2005/131226 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride in water 2 h; Heating;
参考文献
Wozniak, Marian; Baranski, Andrzej; Nowak, Krystyna; Poradowska, Henryka
Liebigs Annalen der Chemie, 1990 , # 7 p. 653 - 657
反应条件
1: 67 percent / DMF, dimethyl acetal / dimethylformamide / 7 h / 110 - 120 °C 2: 59 percent / NH3 / ethanol / 20 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 18 p. 3307 - 3319
反应条件
1: sulfuric acid; nitric acid / water / 0 - 5 °C 2: acetic acid / 40 h / 100 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 7 p. 2049 - 2059
反应条件
ammonium chloride; zinc in tetrahydrofuran; ethanol; water T=30 - 35°C; 2 h;
参考文献
Rehwinkel, Hartmut; Baeurle, Stefan; Berger, Markus; Schmees, Norbert; Schaecke, Heike; Krolikiewicz, Konrad; Mengel, Anne; Nguyen, Duy; Jaroch, Stefan; Skuballa, Werner
Patent: US2005/131226 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
Pd-C in methanol; ethanol; water; acetic acid
参考文献
Warner-Lambert Company
Patent: US5177075 A1, 1993 ;
反应条件
trichlorophosphate 3 h; Heating / reflux;
参考文献
SmithKline Beecham plc
Patent: EP1228043 B1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogenchloride; Pd-C in ethanol
参考文献
Warner-Lambert Company
Patent: US5177075 A1, 1993 ;
反应条件
hydrogenchloride; palladium 10 on activated carbon; hydrogen in ethanol; water
T=20°C; 2 h;
参考文献
Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2049 - 2059
