4-氟-1-甲基-2-(甲基磺酰基)苯合成路线 （共 3 条）
反应条件
1: 5-fluoro-2-methyl-benzenesulphonyl chloride With hydrazine in tetrahydrofuran
T=0°C; 16 h;
2: methyl iodide With sodium acetate in ethanol
16 h; Heating / reflux;
参考文献
GILEAD SCIENCES, INC.
Patent: US2007/72831 A1, 2007 ;
Location in patent: Page/Page column 83 ;
反应条件
trifluorormethanesulfonic acid; antimony trichloride
T=120°C; Friedel-Crafts reaction; 168 h;
参考文献
Peyronneau, Magali; Boisdon, Marie-Therese; Roques, Nicolas; Mazieres, Stephane; Le Roux, Christophe
European Journal of Organic Chemistry, 2004 , # 22 p. 4636 - 4640
反应条件
(i) HSO3F, SbF5, liq. SO2, (ii) /BRN= 1098229/; Multistep reaction;
参考文献
Olah,G.A.; Kiovsky,T.E.
Journal of the American Chemical Society, 1968 , vol. 90, p. 2583 - 2586
