4-氟-3-甲氧基苯甲酸合成路线 （共 16 条）
反应条件
water; sodium hydroxide in methanol T=20°C; 4 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
pyridine; potassium permanganate in water 1.) 50 deg C, 3 h, 2.) RT, 3 h;
参考文献
Claudi, Francesco; Cardellini, Mario; Cingolani, Gian Mario; Piergentili, Alessandro; Pertuzzi, Guidubaldo; Balduini, Walter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2408 - 2412
反应条件
1: 84 percent / K2CO3 / acetone / 5 h / Heating 2: 70 percent / potassium permanganate, pyridine / H2O / 1.) 50 deg C, 3 h, 2.) RT, 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2408 - 2412
反应条件
1: 1.) 6 M sulfuric acid, NaNO2, 2.) CuSO4*5H2O, 96percent H2SO4 / 1.) water, 2.) 165 deg C 2: 84 percent / K2CO3 / acetone / 5 h / Heating 3: 70 percent / potassium permanganate, pyridine / H2O / 1.) 50 deg C, 3 h, 2.) RT, 3 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2408 - 2412
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C 2: sodium hydroxide; water / methanol / 4 h / 20 °C View Scheme
反应条件
sulfuric acid 16 h; Heating;
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
bromine in water; acetic acid T=20 - 50°C;
参考文献
Tetrahedron Letters, , vol. 50, # 12 p. 1267 - 1269
反应条件
1: 95 percent / H2SO4 / 16 h / Heating 2: 62 percent / HNO3; H2SO4 / 0.5 h / 0 - 10 °C 3: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C 4: 68 percent / acetic acid / 135 °C 5: 95 percent / SOCl2 / 16 h / Heating View Scheme
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
1: 95 percent / H2SO4 / 16 h / Heating 2: 62 percent / HNO3; H2SO4 / 0.5 h / 0 - 10 °C 3: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C View Scheme
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
1: 95 percent / borane dimethyl sulfide complex / tetrahydrofuran / 0 - 20 °C 2: 52 percent / MnO2 / CHCl3 / 20 °C 3: 34 percent / BBr3 / CH2Cl2 / -70 °C View Scheme
参考文献
Langer; Dolle; Halldin; Vaufrey; Coulon; Fuseau; Bottlaender; Crouzel
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # SUPPL. 1 p. S504-S506
