4-氟-3-甲氧基苯甲酸合成路线 （共 16 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=0°C; Reduction;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # SUPPL. 1 p. S504-S506
反应条件
1: 95 percent / borane dimethyl sulfide complex / tetrahydrofuran / 0 - 20 °C 2: 52 percent / MnO2 / CHCl3 / 20 °C View Scheme
参考文献
Claudi, Francesco; Cardellini, Mario; Cingolani, Gian Mario; Piergentili, Alessandro; Pertuzzi, Guidubaldo; Balduini, Walter
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2408 - 2412
反应条件
1: 95 percent / H2SO4 / 16 h / Heating 2: 62 percent / HNO3; H2SO4 / 0.5 h / 0 - 10 °C View Scheme
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
thionyl chloride
4 h; Heating;
参考文献
Hartmann; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
反应条件
1: 92 percent / thionyl chloride / 4 h / Heating
2: 1.) CdCl2 / 1.) ether, from -5 deg C to reflux, 1 h, 2.) benzene, reflux, 1 h
View Scheme
参考文献
Hartmann; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 577 - 585
反应条件
1: triethanolamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sulfuric acid / sulfolane
2: ethanol
3: boron tribromide / water; ethyl acetate
View Scheme
参考文献
PFIZER INC.; EDWARDS, Martin Paul; KUMPF, Robert Arnold; KUNG, Pei-Pei; MCAPLINE, Indrawan James; NINKOVIC, Sacha; RUI, Eugene Yuanjin; SUTTON, Scott Channing; TATLOCK, John Howard; WYTHES, Martin James; Zehnder, Luke Raymond
Patent: US2014/179667 A1, 2014 ;
