1: 1.) bis(trimethylsilyl)acetamide / 1.) dichloroethane, reflux, 1 h, 2.) dichloroethane, acetonitrile, RT, 18 h 2: NH3 / methanol / 24 h / Ambient temperature View Scheme

1: K2CO3 / acetone 2: 1.) LDA 3: 87 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating 4: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h 5: NH3(g) / methanol / 18 h / Ambient temperature View Scheme

1: 1.) LDA 2: 87 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating 3: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h 4: NH3(g) / methanol / 18 h / Ambient temperature View Scheme

1: K2CO3 / acetone 2: 1.) LDA 3: 87 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating 4: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h 5: NH3(g) / methanol / 18 h / Ambient temperature View Scheme

1: 87 percent / 20percent aq. chloroacetic acid, AcOH / 18 h / Heating 2: 1.) bis(trimethylsilyl)acetamide / 1.) 1,2-dichloroethane, reflux, 35 min, 2.) 1,2-dichloroethane, CH3CN, RT, 18 h 3: NH3(g) / methanol / 18 h / Ambient temperature View Scheme