2,4-二甲氧基苯乙酮合成路线 （共 100 条）
反应条件
1.1: sulfur; morpholine / 12 h / 130 °C 1.2: 12 h / |Reflux 2.1: boron trifluoride diethyl etherate / 0.17 h / 100 °C 2.2: 0.33 h / 55 °C 2.3: 3 h / 80 °C 3.1: acetic acid; hydrogen; 5 palladium on charcoal / ethanol; water / 12 h / 20 °C 4.1: acetic acid; 3,4,5-trimethoxyphenylboronic acid / toluene / 12 h / |Reflux; |Inert atmosphere 5.1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C View Scheme
参考文献
Ji, Wen-Hua; Gao, Qian-Shan; Lin, Yun-Liang; Gao, Hong-Mei; Wang, Xiao; Geng, Yan-Ling
Synthetic Communications, 2014 , vol. 44, # 4 p. 540 - 546
反应条件
nitric acid in acetic acid
参考文献
Royer,R. et al.
Bulletin de la Societe Chimique de France, 1974 , p. 1691 - 1694
参考文献
Feng; Chiu
Huaxue Xuebao, 1959 , vol. 25, p. 277,285
Chem.Abstr., 1960 , p. 17306
反应条件
ammonium formate; palladium on activated charcoal in acetic acid T=110°C; 0.333333 h;
参考文献
Ram, Siya; Spicer, Leonard D.
Tetrahedron Letters, 1988 , vol. 29, # 31 p. 3741 - 3744
反应条件
hydrogenchloride; sodium cyanoborohydride in methanol 24 h; Product distribution;
参考文献
Elliger, Carl A.
Synthetic Communications, 1985 , vol. 15, # 14 p. 1315 - 1324
参考文献
Boucherle,A. et al.
Chimica Therapeutica, 1968 , vol. 3, p. 256 - 259
反应条件
1: AlCl3; benzene / 100 - 110 °C 2: acetic acid; nitric acid 3: tin; tin (II)-chloride; aqueous hydrochloric acid / weiteres Reagens: Essigsaeure 4: aqueous H2SO4; NaNO2 / und Erhitzen der erhaltenen Diazoniumsalz-Loesung mit CuSO4,<NH4>2SO4,Na2SO4 und wss.H2SO4 View Scheme
参考文献
Shinoda; Sato; Kawagoye
Yakugaku Zasshi, 1932 , vol. 52, p. 766,773;dtsch.Ref.S.91
Chem.Abstr., 1933 , p. 295
反应条件
1: copper(ll) bromide / ethyl acetate / 1.5 h / Reflux 2: ethanol / 1 h / Reflux View Scheme
参考文献
TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson
Patent: WO2013/82324 A1, 2013 ;
反应条件
1: SO2Cl2 / CHCl3 / Heating 2: (i) Py, (ii) aq. NaOH View Scheme
参考文献
Royer,R. et al.
Bulletin de la Societe Chimique de France, 1969 , p. 878 - 882
反应条件
pyridinium p-toluenesulfonate 0.0333333 h; microwave irradiation;
参考文献
Lamba, Mandeep S.; Makrandi, Jagdish K.
Journal of Chemical Research, 2007 , # 10 p. 585 - 586
