2,4-二甲氧基苯乙酮合成路线 （共 100 条）
反应条件
sodium hydroxide in ethanol T=20°C;
参考文献
Gaur, Rashmi; Yadav, Kuldeep Singh; Verma, Ram Kishor; Yadav, Narayan Prasad; Bhakuni, Rajendra Singh
Phytomedicine, 2014 , vol. 21, # 4 p. 415 - 422
反应条件
in ethanol Claisen Schmidt condensation; Basic conditions;
参考文献
Rathish; Javed, Kalim; Ahmad, Shamim; Bano, Sameena; Alam; Pillai; Singh, Surender; Bagchi, Vivek
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 255 - 258
反应条件
1: sulfur / 6 h / 130 °C
2: sodium hydroxide / water / 3 h / 100 - 102 °C
3: triethylamine
4: potassium carbonate / methanol
5: potassium carbonate / N,N-dimethyl-formamide
6: N-bromosuccinmide; lithium hexamethyldisilazane / tetrahydrofuran
View Scheme
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Adams, Richard; Ma, Robert; Beish, Sandra; Branum, Shawn; Youells, Scott; Roberts, Jerry; Jain, Nareshkumar; Kanojia, Ramesh; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 414 - 421
反应条件
1: NaNH2; diethyl ether
2: potassium iodide; phosphoric acid
View Scheme
参考文献
Spatz; Koral
Journal of Organic Chemistry, 1959 , vol. 24, p. 1381
反应条件
1: sodium / 125 °C
2: aqueous hydriodic acid / 130 °C
3: aqueous hydriodic acid; phenol
View Scheme
参考文献
Hattori
Acta Phytochimica, 1932 , vol. 6, p. 131,152
反应条件
1: OH- / ethanol
2: 1.9 g / H2O2, OH-
3: 850 mg / H2 / Pd-BaSO4 / methanol / 10 h / Ambient temperature
View Scheme
参考文献
Bezuidenhoudt, Barend C. B.; Brandt, E. Vincent; Roux, David G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 263 - 269
反应条件
1: 1) m-chloroperbenzoic acid / 2) Hydrolysis
2: 27 percent / NaOH
View Scheme
参考文献
Joseph-Nathan; Dominguez; Ortega
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 1141 - 1144
反应条件
potassium tert-butylate in tetrahydrofuran; tert-butyl methyl ether
T=20°C; Inert atmosphere;
参考文献
Carpino, Philip A.; Conn, Edward L.; Dow, Robert L.; Dowling, Matthew S.; Hepworth, David; Kung, Daniel Wei-Shung; Orr, Suvi; Rocke, Benjamin N.; Ruggeri, Roger B.; Sammons, Matthew F.; Warmus, Joseph S.; Zhang, Yan
Patent: US2013/123230 A1, 2013 ;
Location in patent: Paragraph 0260; 0261; 0262 ;
反应条件
1: conc. hydrochloric acid / ethanol / 8 h / Heating
2: 7.2 g / diethyl ether / 0 °C
3: 90 percent / 170 °C / 0.2 Torr
View Scheme
参考文献
Carter, Rachel H.; Garson, Mary J.; Hill, Robert A.; Staunton, James; Sunter, David C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 471 - 479
反应条件
sodium hydride in benzene
3 h;
参考文献
Choshi; horimoto; Wang; Nagase; Ichikawa; Sugino; Hibino
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 4 p. 1047 - 1049
