1-[3-(3,4-亚甲基二氧基苯氧基)丙基]-4-苯基哌嗪马来酸盐合成路线 （共 3 条）
反应条件
lithium carbonate in acetonitrile
24 h; Heating / reflux;
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1.1: potassium carbonate / acetone / 27 h / 20 °C
2.1: dimethylsulfide borane complex / dichloromethane / 5 h / 20 °C / Darkness; Inert atmosphere
2.2: 20 h / 20 °C
3.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4.1: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2: lithium carbonate / acetonitrile / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Romeiro, Luiz A.S.; Da Silva Ferreira, Marcos; Da Silva, Leandro L.; Castro, Helena C.; Miranda, Ana L.P.; Silva, Claudia L.M.; Noel, Franois; Nascimento, Jessica B.; Araujo, Claudia V.; Tibirica, Eduardo; Barreiro, Eliezer J.; Fraga, Carlos A.M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3000 - 3012
